DNA repair is important in such phenomena as carcinogenesis and aging. While much is known about DNA repair in single‐cell systems such as bacteria, yeast, and cultured mammalian cells, it is necessary to examine DNA repair in a developmental context in order to completely understand its processes in complex metazoa such as man. We present data to support the notion that proliferating cells from organ systems, tumors, and embryos have a greater DNA repair capacity than terminally differentiated, nonproliferating cells. Differential (...) expression of repair genes and accessibility of chromatin to repair enzymes are considered as determinants in the developmental regulation of DNA repair. (shrink)

My poetized culture is one which has given up the attempt to unite one’s private ways of dealing with finitude and one’s sense of obligation to other human beings.Richard Rorty repudiated W. B. Yeats’s aspiration “to hold justice and reality in a single vision,” and he did so with relish.2 Thrilling though it is, Rorty would say, there is no need to weave into a single, coherent narrative our commitment to the end of cruelty (justice) and our idiosyncratic aesthetic tastes (...) (reality). We can affirm both principles individually—justice and reality—without concocting a “philosophy of life” (or finding a “philosophical slop-shop”3) that will draw straight lines from aesthetic obsession to justice work. Allowing .. (shrink)

What is the relationship between natural science, social science, and religion? The dominant paradigm in contemporary social science is scientism, the attempt to apply the methods of natural science to the study of society. However, scientism is problematic: it rests on a conception of natural science that cannot be sustained. Natural scientific understanding emerges from an instrumental and objectifying relation to the world; it is oriented toward control and manipulation of the physical world. Social‐scientific understanding, by contrast, must begin with (...) a practical and meaningful relation to the world: it is oriented toward the mediation of values and objective possibilities in the social world. Social science is therefore a form of practical reason based on objective claims. But while social‐scientific understanding starts with interpretation, its possibilities by no means end there. In particular, by developing abstract and objectified models of society as a system, social science opens existing social organization to critical reflection. Religion, by contrast, is a form of speculative reason about ultimate values, based on subjective claims of religious experience. Social science nevertheless shares with religion an orientation toward values and concern with the “good life.”. (shrink)

This anthology examines the practical role of well-being in contemporary society. It discusses developments such as globalization, consumerism and the rapid innovation and use of new and emerging technologies and focuses on the significant impact of these developments on the well-being of people living today. The anthology brings together researchers from various disciplines, including psychology, economics, sociology, philosophy and development studies. It provides concrete insight on the role and importance of well-being in contemporary society, using a mix of empirical grounding, (...) philosophical rigour and an emphasis on real-world applications. It is unique in that it seeks to understand the relation between well-being research and its application towards real problems. (shrink)

We present the first neurophysiological signatures showing distinctive effects of group social context and emotional arousal on cultural perceptions, such as the efficacy of religious rituals. Using a novel protocol, EEG data were simultaneously recorded from ethnic Chinese religious believers in group and individual settings as they rated the perceived efficacy of low, medium, and high arousal spirit-medium rituals presented as video clips. Neural oscillatory patterns were then analyzed for these perceptual judgements, categorized as low, medium, and high efficacy. The (...) results revealed distinct neural signatures and behavioral patterns between the experimental conditions. Arousal levels predicted ratings of ritual efficacy. Increased efficacy was marked by suppressed alpha and beta power, regardless of group or individual setting. In groups, efficacy ratings converged. Individual setting showed increased within-participant phase synchronization in alpha and beta bands, while group setting enhanced between-participant theta phase synchronization. This reflected group participants' orientation toward a common perspective and social coordination. These findings suggest that co-presence in groups leads to a social-tuning effect supported by between-participant theta phase synchrony. Together these neural synchrony patterns reveal how collective rituals have both individual and communal dimensions. The emotionality of spirit-medium rituals drives individual perceptions of efficacy, while co-presence in groups signals the significance of an event and socially tunes enhanced agreement in perceptual ratings. In other words, mass gatherings may foster social cohesion without necessarily requiring group-size scaling limitations of direct face-to-face interaction. This could have implications for the scaling computability of synchrony in large groups as well as for humanistic studies in areas such as symbolic interactionism. (shrink)

Reviews the basic Catholic moral principles that apply to health care, then uses them to assess three major current trends in the health care industry.

This book shows how time is a fundamental element in our perception of the arts and proposes an integrated framework within which to explore and appreciate the subtleties and complexities of this essential key to the reading and understanding of meaning in art. The book is a work of ideas, not abstract theory or pure art history. It offers wide-ranging insight into the aesthetics and philosophies of time across different art forms, cultures, and periods. Intended for both arts practitioners and (...) anyone wishing to extend their understanding of the creative process and its underlying principles, the book reveals the interplay of art and time from technical execution and formal invention to the spiritual and intuitive. It opens up fresh possibilities for artists to develop their work in new directions, and for the visitor to engage with artworks including architecture, drawing, sculpture, painting, and photography, in challenging and fulfilling new ways. (shrink)

This book examines the U.S economy from 1967 to 2011 and utilizes a new method to predict the future of the economy as far ahead as 2030. Projections using estimates from the U.S. Bureau of Census are used to further project personal income, personal income annual change, and disposable personal income to 2030.

Any author should be happy when commentators on a long book discuss it thoroughly, raise important issues, and show their sensitivity to its main themes. So I want to begin with thanks to Isaac Levi, Peter Machamer, Richard Miller and Dudley Shapere. This is not, of course, to register agreement with all their criticisms. Indeed, that would be impossible, for their perspectives are so varied as to resist integration into a consistent synthesis. Nevertheless, each of them poses problems that my (...) approach to the growth of scientific knowledge must address, and I believe that the combination of their essays greatly advances the discussion. (shrink)

Imitation has been understood in different ways: as a cognitive adaptation subtended by genetically specified cognitive mechanisms; as an aspect of domain general human cognition. The second option has been advanced by Cecilia Heyes who treats imitation as an instance of associative learning. Her argument is part of a deflationary treatment of the “mirror neuron” phenomenon. I agree with Heyes about mirror neurons but argue that Kim Sterelny has provided the tools to provide a better account of the nature and (...) role of human imitation. What we call imitative learning is an instance of social learning. It has little to do with empathy, emotional contagion, or mind reading. (shrink)

Using a classical conditioning technique, this study investigated whether nonconscious associative learning could be indexed by event-related brain activity . There were three phases. In a preconditioning baseline phase, pleasant and unpleasant facial schematics were presented in awareness . A conditioning phase followed, in which stimuli were presented outside awareness , with an unpleasant face linked to an aversive shock and a pleasant face not linked to a shock. The third, postconditioning phase, involved stimulus presentations in awareness . Evidence for (...) acquisition of a conditional response was sought by comparing suprathreshold pre- and postconditioning phases, as well as in the subthreshold conditioning phase itself. For the pre-postconditioning phase analyses, significant ERP component differences differentiating CS+ and CS− were observed for N1, P2, and especially P3. For the conditioning phase, significant differences were observed in the 100–400 ms. post-stimulus region reflecting a CS+ processing negativity. Brain activity does indeed index the acquisition of a conditional response to subthreshold stimuli. Associative learning can occur outside awareness. (shrink)

Using a classical conditioning technique, this study investigated whether nonconscious associative learning could be indexed by event-related brain activity . There were three phases. In a preconditioning baseline phase, pleasant and unpleasant facial schematics were presented in awareness . A conditioning phase followed, in which stimuli were presented outside awareness , with an unpleasant face linked to an aversive shock and a pleasant face not linked to a shock. The third, postconditioning phase, involved stimulus presentations in awareness . Evidence for (...) acquisition of a conditional response was sought by comparing suprathreshold pre- and postconditioning phases, as well as in the subthreshold conditioning phase itself. For the pre-postconditioning phase analyses, significant ERP component differences differentiating CS+ and CS− were observed for N1, P2, and especially P3. For the conditioning phase, significant differences were observed in the 100–400 ms. post-stimulus region reflecting a CS+ processing negativity. Brain activity does indeed index the acquisition of a conditional response to subthreshold stimuli. Associative learning can occur outside awareness. (shrink)

The contemporary sociology of morality is a form of descriptive ethics that shrinks away from any sort of prescriptive ethics. Building on the moral philosophies of John Dewey, and also of Alasdair MacIntyre and Paul Ricoeur, and in dialogue with recent work by Stefan Bargheer, this article proposes a more ambitious program of critical social ethics that connects concerns with character and the common good but tempers them with attention to alienation and oppression.